14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Base Information

Chemical Name:14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)
CAS No.:852836-62-5
Molecular Formula:C₂₉H₃₃NO₅
Molecular Weight:475.585
Hs Code.:

Synonyms:14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

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Chemical Property of 14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

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Technology Process of 14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

There total 3 articles about 14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852836-61-4
3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

: 106-95-6
allyl bromide

: 852836-62-5
14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Guidance literature:: 3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane); With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h; cooling;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1021/jm040894o

Reference yield:

: 76-41-5
oxymorphone

: 852836-62-5
14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 percent / methanesulfonic acid / 24 h / Heating

2.1: 42 percent / potassium carbonate / dimethylformamide / 42 h / 85 °C

3.1: NaH / dimethylformamide / 0.33 h / cooling

3.2: dimethylformamide / 6 h / 20 °C

With methanesulfonic acid; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm040894o

Reference yield:

: 263713-08-2
4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

: 852836-62-5
14-allyloxy-3-benzyloxy-4,5α-epoxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Guidance literature:: Multi-step reaction with 2 steps

1.1: 42 percent / potassium carbonate / dimethylformamide / 42 h / 85 °C

2.1: NaH / dimethylformamide / 0.33 h / cooling

2.2: dimethylformamide / 6 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm040894o