N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

Base Information

Chemical Name:N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide
CAS No.:1352550-08-3
Molecular Formula:C₁₇H₁₉N₃O₄
Molecular Weight:329.356
Hs Code.:

N<sub>2</sub>-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N<sub>1</sub>-cyclopropyl-L-serinamide

Synonyms:N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

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Technology Process of N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

There total 3 articles about N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 670253-52-8
N₁-cyclopropylserinamide hydrochloride

: 14378-08-6
(E)-2-cyano-3-(4-methoxyphenyl)acrylic acid

: 1352550-08-3
N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 2h;
DOI:10.1016/j.bmc.2011.10.061

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1352550-08-3
N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methyl-piperazine / methanol / 20 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

With 1-methyl-piperazine; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide; 1: Aldol condensation;
DOI:10.1016/j.bmc.2011.10.061

Reference yield:

: 1352550-45-8
N₂-(tert-butyloxycarbonyl)-N₁-cyclopropylserinamide

: 1352550-08-3
N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; ethyl acetate / 24 h / 4 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.061