14378-08-6

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 372-09-8 cyanoacetic acid 
• 105-56-6 ethyl 2-cyanoacetate 
• 142-08-5 2-Pyridone 
• 135-02-4 ortho-anisaldehyde 
• 154198-90-0 (E)-3-p-anisyl-2-cyano-2-propenoyl azide 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 

Downstream Products

• 80540-67-6 p-nitrophenyl 2-cyano-3-(p-methoxyphenyl)propenoate 
• 30115-95-8 (Z)-3-(4-methoxy-phenyl)-acrylonitrile 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 
• 23297-32-7 cyanoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 31007-06-4 2-(4-methoxyphenyl)propionitrile 
• 1352550-07-2 methyl N-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-L-serinate 
• 1352550-08-3 N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide 
• 36397-19-0 α-Cyano-β-(4-methoxyphenyl)propionic acid 
• 5349-42-8 (5Z)-5-(4-methoxybenzylidene)imidazolidine-2,4-dione 
• 154199-10-7 [1-Cyano-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 154199-09-4 2-Cyano-3-(4-methoxy-phenyl)-propionyl azide 

Relevant academic research and scientific papers

Enhanced antioxidation capacity endowed to a mixed type aldose reductase inhibitor leads to a promising anti-diabetic complications agent

A series of 5f-based new compounds has been designed and synthesized. In vitro screening demonstrated that the binding affinity and selectivity on aldose reductase (AR) were positively correlated with its antioxidation capacity. Compound 6d was verified t

Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent

A simple and selective green methodology has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and α,β-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct.

Discovery of Novel Celastrol Derivatives as Hsp90-Cdc37 Interaction Disruptors with Antitumor Activity

To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. Among all the target compounds, 41 wa

Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents

Oxidative stress plays a significant role in the pathogenesis of various human diseases. In this study, a series of bifendate derivatives bearing acrylamide moiety were synthesized and evaluated as anti-oxidant agents. Biological evaluation indicated that

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the central double bond have a crucial influence on the activity of the compounds, whereas the influence of substituents of the amide residue is less relevant. The para-hydroxy substituted analog was found to be the most potent inhibitor in this series with a Ki-value of 35.7 μM at the Dengue and 44.6 μM at the West Nile virus protease. The aprotinin competition assay demonstrates a direct interaction of the inhibitor molecule with active centre of the Dengue virus protease. The target selectivity was studied in a counterscreen with thrombin and found to be 2.8:1 in favor of DEN protease and 2.3:1 in favor of WNV protease, respectively.

CO2 absorbing cost-effective ionic liquid for synthesis of commercially important alpha cyanoacrylic acids: A safe process for activation of cyanoacetic acid

Cost-effective and carbon dioxide absorbing ionic liquid, tri-(2-hydroxyethyl) ammonium acetate, was shown to perform multiple roles in Knoevenagel condensation. It acted as an environmentally benign solvent, as an activating catalyst for the less reactive cyanoacetic acid and also as a risk reduction medium for the unevenly generated large amount of CO2 gas for large scale reactions. The reaction was scaled up for multi-gram synthesis of commercially important alpha cyanoacrylic acids.

Synthesis and transformations of derivatives and analogs of α-cyanocinnamic acid

A reaction of ethyl α-cyanoacetate with 5-arylfurfurals, furfural, and 4-methoxybenzaldehyde in alkaline water medium gives rise to 3-substituted 2-cyanoacrylic acids in high yield. The reaction of the corresponding acyl chlorides with diethylamine and an

Knoevenagel condensation in heterogeneous phase catalyzed by IR radiation and Tonsil Actisil FF

Infrared radiation promoted the synthesis of benzylidenemalononitriles, benzylidenecyanoacetamides and benzylidenecyanoacetic acids by condensation of aromatic aldehydes with the corresponding active methylene compound in the presence of Tonsil Actisil FF, without solvent. Mass of catalyst, solvent, and reaction time were assessed in order to improve the efficiency of this process.

Synthesis and insecticidal activity of novel acrylonitrile derivatives

(E)-3-p-Anisyl-2-cyano-2-propenoyl chloride and/or azide (1b and c) underwent successful nucleophilic displacement reactions, with urea and thiourea derivatives to give the mono-or di-displacement products (4, 8, 2 and 5) respectively, beside other cyclic

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.