N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

Base Information

Chemical Name:N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine
CAS No.:1308870-42-9
Molecular Formula:C₃₂H₂₈BrN₃O
Molecular Weight:550.498
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

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Chemical Property of N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

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Technology Process of N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

There total 10 articles about N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308870-41-8
3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-2-chloro-6-o-tolylquinoline

: 2393-23-9
4-methoxy-benzylamine

: 1308870-42-9
N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 1.16667h;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1308870-42-9
N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / Cooling with ice; Sealed tube; Inert atmosphere

1.2: 48.5 h / 75 °C

1.3: Cooling with ice

2.1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C

3.1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 2 h / Reflux

4.1: manganese(IV) oxide / dichloromethane

5.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 °C / Inert atmosphere

5.2: 1.67 h / 20 °C / Cooling with ice

6.1: 1-methyl-pyrrolidin-2-one / 1.17 h / 200 °C

With manganese(IV) oxide; sodium tetrahydroborate; ethanol; potassium acetate; potassium hexamethylsilazane; trichlorophosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1017464-16-2
(6-bromo-2-chloroquinolin-3-yl)methanol

: 1308870-42-9
N-(4-methoxybenzyl)-3-(2-(5-bromopyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 2 h / Reflux

2.1: manganese(IV) oxide / dichloromethane

3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 1.67 h / 20 °C / Cooling with ice

4.1: 1-methyl-pyrrolidin-2-one / 1.17 h / 200 °C

With manganese(IV) oxide; potassium acetate; potassium hexamethylsilazane; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene; acetonitrile;