3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Base Information

Chemical Name:3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one
CAS No.:1445869-04-4
Molecular Formula:C₂₅H₂₂FN₅O₅
Molecular Weight:491.479
Hs Code.:

Synonyms:3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

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Chemical Property of 3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

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Technology Process of 3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

There total 7 articles about 3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 698-63-5
5-nitrofurane-2-carboxaldehyde

: 1445869-38-4
5-[1-(4-amino-2-fluorophenyl)-4-piperidyl]-3-benzyl-2,3-dihydro-1,3,4-oxadiazol-2-one

: 1445869-04-4
3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Guidance literature:: With acetic acid; In methanol; at 0 ℃; for 10h;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1445869-04-4
3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 12 h / Reflux

3: pyridine / 2.5 h / 85 °C / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 27 °C

5: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

6: acetic acid / methanol / 10 h / 0 °C

With pyridine; tin(II) chloride dihdyrate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1445869-04-4
3-benzyl-5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]amino phenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 12 h / Reflux

3: pyridine / 2.5 h / 85 °C / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 27 °C

5: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

6: acetic acid / methanol / 10 h / 0 °C

With pyridine; tin(II) chloride dihdyrate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;