6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:1421253-70-4
Molecular Formula:C₃₃H₃₅N₅O₃S
Molecular Weight:581.739
Hs Code.:

Synonyms:6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Chemical Property of 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 6 articles about 6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

: 1421253-69-1
4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-70-4
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In tetrahydrofuran; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 499-75-2
carvacrol

: 1421253-70-4
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: XPhos; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 1 h / 140 °C / Microwave irradiation

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1421067-10-8
6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-70-4
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1-tosyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 140 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 0.33 h

3.1: acetic acid; 10% palladium hydroxide on charcoal; hydrogen / water / 2.5 h / 20 °C / 760.05 Torr

4.1: XPhos; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 1 h / 140 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10% palladium hydroxide on charcoal; hydrogen; sodium hydride; sodium carbonate; caesium carbonate; acetic acid; XPhos; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil;