2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:1421251-01-5
Molecular Formula:C₂₆H₂₈ClN₅O
Molecular Weight:461.994
Hs Code.:

Synonyms:2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Chemical Property of 2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 9 articles about 2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421250-96-5
6-(5-isopropyl-2-methylphenyl)-4-methoxy-2-(5-methyl-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421251-01-5
2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: With sodium hypochlorite; In ethanol; water; at 0 ℃;

Reference yield:

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

: 1421251-01-5
2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: XPhos; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 1 h / 140 °C / Microwave irradiation

2: ammonium hydroxide; potassium hydroxide / methanol; water / 0.5 h / 80 °C / Microwave irradiation

3: sodium hypochlorite / water; ethanol / 0 °C

With ammonium hydroxide; sodium hypochlorite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; potassium hydroxide; XPhos; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 499-75-2
carvacrol

: 1421251-01-5
2-(3-chloro-5-methyl-1H-indazol-4-yl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: XPhos; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 1 h / 140 °C / Microwave irradiation

3: ammonium hydroxide; potassium hydroxide / methanol; water / 0.5 h / 80 °C / Microwave irradiation

4: sodium hypochlorite / water; ethanol / 0 °C

With pyridine; ammonium hydroxide; sodium hypochlorite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; potassium hydroxide; XPhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;