methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

Base Information

Chemical Name:methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique
CAS No.:76146-50-4
Molecular Formula:C₃₇H₄₆N₄O₉
Molecular Weight:690.794
Hs Code.:

methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

Synonyms:methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

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Chemical Property of methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

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Technology Process of methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

There total 4 articles about methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: tosylate de l'ester benzylique de l'acide 1-methylhydrazinoacetique

: 76146-46-8
acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

: 76146-50-4
methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

Guidance literature:: With dicyclohexyl-carbodiimide; In triethylamine; acetonitrile; at 0 - 20 ℃; for 6h; 1. 2h 0 gradC; 2. 4h 20 gradC;
DOI:10.1016/0040-4020(80)80072-X

Reference yield:

: 76146-53-7,119962-75-3,131903-13-4
lactone de l'acide (3RS-5RS) hydroxy-5 bis(((phenylmethoxy)carbonyl)amino)-3,6 hexanoique

: 76146-50-4
methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 4N NaOH / H₂O / 2 h / 20 °C

2: 56 percent / acide p. toluene sulfonique / CHCl₃ / 3 h / 20 °C

3: 93 percent / 1N NaOH / methanol; H₂O / 2.5 h / Heating

4: 75 percent / dicyclohexylcarbodiimide / acetonitrile; triethylamine / 6 h / 0 - 20 °C / 1. 2h 0 gradC; 2. 4h 20 gradC

With sodium hydroxide; acide p. toluene sulfonique; dicyclohexyl-carbodiimide; In methanol; chloroform; water; triethylamine; acetonitrile;
DOI:10.1016/0040-4020(80)80072-X

Reference yield:

: 76146-41-3
(3RS-5RS) hydroxy-5 bis(((phenylmethoxy)carbonyl)amino)-3,6 hexanoate de methyle

: 76146-50-4
methyl-2 (((phenylmethoxy)carbonyl)methyl)-2-hydrazide de l'acide (3RS-5RS) bis(((phenylmethoxy)carbonyl)amino)-3,6 (2-(tetrahydropyrannyloxy))-5 hexanoique

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / acide p. toluene sulfonique / CHCl₃ / 3 h / 20 °C

2: 93 percent / 1N NaOH / methanol; H₂O / 2.5 h / Heating

3: 75 percent / dicyclohexylcarbodiimide / acetonitrile; triethylamine / 6 h / 0 - 20 °C / 1. 2h 0 gradC; 2. 4h 20 gradC

With sodium hydroxide; acide p. toluene sulfonique; dicyclohexyl-carbodiimide; In methanol; chloroform; water; triethylamine; acetonitrile;
DOI:10.1016/0040-4020(80)80072-X