(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

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Chemical Name:(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone
CAS No.:1597522-50-3
Molecular Formula:C₂₃H₁₉F₃N₆O₃
Molecular Weight:484.437
Hs Code.:

Synonyms:(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

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Chemical Property of (5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

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Technology Process of (5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

There total 9 articles about (5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1293284-52-2
4-chloro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

: 3-(S)-pyrrolidin-2-yl-5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazole

: 1597522-50-3
(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

Guidance literature:: 4-chloro-2-(2H-1,2,3-triazol-2-yl)benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.25h; Inert atmosphere;

3-(S)-pyrrolidin-2-yl-5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazole; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/cmdc.201900618

Reference yield: 70.0%

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 3-(S)-pyrrolidin-2-yl-5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazole

: 1597522-50-3
(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone

Guidance literature:: 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

3-(S)-pyrrolidin-2-yl-5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazole; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201900242