1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate
CAS No.:699011-76-2
Molecular Formula:C₁₃H₁₄F₃NO₅S₂
Molecular Weight:385.385
Hs Code.:

Synonyms:1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

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Chemical Property of 1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

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Technology Process of 1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

There total 7 articles about 1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 456-64-4
phenyl trifluoromethanesulfonamide

: 23438-61-1
1-(toluene-4-sulfonyl)piperidin-2-one

: 699011-76-2
1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

Guidance literature:: 1-(toluene-4-sulfonyl)piperidin-2-one; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃;

phenyl trifluoromethanesulfonamide; In tetrahydrofuran; toluene; at -78 ℃; for 1h;
DOI:10.1021/jo0493572

Reference yield: 80.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 23438-61-1
1-(toluene-4-sulfonyl)piperidin-2-one

: 699011-76-2
1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

Guidance literature:: 1-(toluene-4-sulfonyl)piperidin-2-one; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 17h; Further stages.;
DOI:10.1002/ejoc.200601089

Reference yield:

: 675-20-7
piperidin-2-one

: 699011-76-2
1-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 82 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

2.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / -78 °C

2.2: 87 percent / tetrahydrofuran; toluene / 1 h / -78 °C

With n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo0493572