diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

Base Information

Chemical Name:diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate
CAS No.:1428526-44-6
Molecular Formula:C₂₁H₂₉N₂O₅P
Molecular Weight:420.445
Hs Code.:

Synonyms:diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

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Chemical Property of diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

Chemical Property:

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Technology Process of diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

There total 8 articles about diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1428526-43-5
tert-butyl N-[(6-bromopyridin-3-yl)(phenyl)methyl]carbamate

: 762-04-9
phosphonic acid diethyl ester

: 1428526-44-6
diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In tetrahydrofuran; Reflux; Inert atmosphere;

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 1428526-44-6
diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 3 h / Reflux

2: aluminum (III) chloride / 6 h / Reflux

3: hydroxylamine hydrochloride; sodium carbonate / ethanol / 3 h / Reflux

4: sodium tetrahydroborate; titanium tetrachloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

With aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 80100-16-9
(6-bromopyridin-3-yl)(phenyl)methanone

: 1428526-44-6
diethyl (5-{[(tert-butoxycarbonyl)amino](phenyl)methyl}pyridin-2-yl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 3 h / Reflux

2: sodium tetrahydroborate; titanium tetrachloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;