ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate

Base Information

• Chemical Name: ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate
• CAS No.: 102101-10-0
• Molecular Formula: C₁₄H₁₆N₂O₂S
• Molecular Weight: 276.359
• Mol file: 102101-10-0.mol

Synonyms:ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate

Chemical Property of ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate

There total 2 articles about ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate (17823-58-4) + 1-amino-3-methylbenzene (108-44-1) → ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate (102101-10-0)

Guidance literature:

In methanol; for 12h; Reflux;

DOI:10.1016/j.tetlet.2017.01.028

Reference yield:

ethyl 2-cyanoacetate (105-56-6) + 3-methylphenyl isothiocyanate (621-30-7) + methyl iodide (74-88-4) → ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate (102101-10-0)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane;

DOI:10.1002/mrc.1024

Reference yield:

ethyl (E)-2-cyano-3-(3-methylphenylamino)-3-(methylthio)acrylate (102101-10-0) → ethyl 5-amino-3-(3-methylphenylamino)pyrazole-4-carboxylate

Guidance literature:

With hydrazine; In methanol; at 160 ℃; for 0.166667h; chemoselective reaction; Microwave irradiation;

DOI:10.1016/j.tetlet.2017.01.028

upstream raw materials:

ethyl 2-cyanoacetate

3-methylphenyl isothiocyanate

methyl iodide

ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate