1-(3-Methylphenyl)-1-phenylethanol

Base Information

• Chemical Name: 1-(3-Methylphenyl)-1-phenylethanol
• CAS No.: 90862-32-1
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.291
• Mol file: 90862-32-1.mol

Synonyms:1-(3-Methylphenyl)-1-phenylethanol

Chemical Property of 1-(3-Methylphenyl)-1-phenylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(3-Methylphenyl)-1-phenylethanol

There total 8 articles about 1-(3-Methylphenyl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4,6-tris(m-tolyl)boroxine (79421-98-0) + acetophenone (98-86-2) → 1-(3-Methylphenyl)-1-phenylethanol (90862-32-1)

Guidance literature:

2,4,6-tris(m-tolyl)boroxine; acetophenone; With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium carbonate; In toluene; at 90 - 110 ℃;

With hydrogenchloride; In water; toluene;

DOI:10.1021/ol300275s

Reference yield: 82.0%

3-Iodotoluene (625-95-6) + acetophenone (98-86-2) → 1-(3-Methylphenyl)-1-phenylethanol (90862-32-1)

Guidance literature:

3-Iodotoluene; With TurboGrignard; In tetrahydrofuran; at 20 ℃;

acetophenone; In tetrahydrofuran; at 20 ℃; under 7757.43 Torr;

With ammonium chloride; In tetrahydrofuran; water;

DOI:10.1021/op200275d

Reference yield:

methyllithium (917-54-4) → 1,1-diphenylethanol (599-67-7) + 1-(3-Methylphenyl)-1-phenylethanol (90862-32-1)

Guidance literature:

In diethyl ether; at 0 ℃; competition reaction with bezophenone and 3-methylbenzophenone, relative velocity constant;

DOI:10.1021/ja00248a027

upstream raw materials:

3-Methylacetophenone

methyllithium

3-methyl benzophenone

methyl iodide

Downstream raw materials:

4-nitro-benzoic acid 1-phenyl-1-m-tolyl-ethyl ester

p-Tolyl-carbamic acid 1-phenyl-1-m-tolyl-ethyl ester

Refernces

• 1、 Fernández-Mateos, Emilio,Maciá, Beatriz,Yus, Miguel. "Catalytic Enantioselective Addition of Aryl Grignard Reagents to Ketones". . p. 6519 - 6526. Retrieved 2016/02/18.
• 2、 Brodmann, Tobias,Koos, Peter,Metzger, Albrecht,Knochel, Paul,Ley, Steven V.. "Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring". experimental part. p. 1102 - 1113. Retrieved 2012/08/27.