8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde

Base Information

• Chemical Name: 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde
• CAS No.: 1415935-02-2
• Molecular Formula: C₂₃H₂₆BF₂N₃O
• Molecular Weight: 409.287
• Mol file: 1415935-02-2.mol

Synonyms:8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde

Chemical Property of 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde

There total 3 articles about 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

propylamine (107-10-8,42939-71-9) + 3-chloro-8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde (1415935-04-4) → 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde (1415935-02-2)

Guidance literature:

In acetonitrile; at 20 ℃; for 4h;

DOI:10.1039/c2ob26791h

Reference yield:

2,4-dimethyl-3-ethyl-pyrrole (517-22-6) + propylamine (107-10-8,42939-71-9) + boron trifluoride diethyl etherate (109-63-7) + C12H8ClNO2 → 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde (1415935-02-2)

Guidance literature:

C₁₂H₈ClNO₂; With trichlorophosphate; In dichloromethane; at 20 ℃; for 3h;

2,4-dimethyl-3-ethyl-pyrrole; In dichloromethane; for 36h;

propylamine; boron trifluoride diethyl etherate; Further stages;

Reference yield:

3-chloro-5,7-dimethyl-6-ethyl-8-phenyl-BODIPY (1355953-59-1) → 8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-3-(propylamino)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde (1415935-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.58 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 2 h / 50 °C / Inert atmosphere

2.1: acetonitrile / 4 h / 20 °C

With trichlorophosphate; In acetonitrile; 1.2: |Vilsmeier-Haack Formylation;

DOI:10.1039/c2ob26791h

upstream raw materials:

3-chloro-5,7-dimethyl-6-ethyl-8-phenyl-BODIPY

propylamine

3-chloro-8-ethyl-5,5-difluoro-7,9-dimethyl-10-phenyl-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine-2-carbaldehyde

2,4-dimethyl-3-ethyl-pyrrole

Downstream raw materials:

C₂₈H₃₀BF₂N₃O₃

C₂₆H₂₅BF₂N₄O

C₂₈H₃₁BF₂N₄O₂

C₂₇H₂₈BF₂N₃O₂