ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE

Base Information

• Chemical Name: ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE
• CAS No.: 22531-51-7
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.274
• Mol file: 22531-51-7.mol

Synonyms:ethyl 2-(2-methoxy-1-naphthyl)-2-oxoacetate

Chemical Property of ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE

Chemical Property:

• Vapor Pressure: 3.66E-07mmHg at 25°C
• Melting Point: 73-74 °C
• Boiling Point: 238-240 °C(Press: 12 Torr)
• Density: 1.198±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-methoxy-1-naphthoylformate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE

There total 4 articles about ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-chloro-1-methyl-naphthalene (17075-39-7) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-(2-methoxy-1-naphthyl)-2-oxoacetate (22531-51-7)

Guidance literature:

4-chloro-1-methyl-naphthalene; With lithium; In diethyl ether; at 20 ℃; for 3h;

With copper(l) cyanide; In tetrahydrofuran; diethyl ether; for 0.25h; Cooling with ice;

Ethyl oxalyl chloride; In tetrahydrofuran; diethyl ether; for 0.666667h; Cooling with ice;

DOI:10.1021/ol302672n

Reference yield:

2-Methoxynaphthalene (93-04-9) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-(2-methoxy-1-naphthyl)-2-oxoacetate (22531-51-7)

Guidance literature:

With carbon disulfide; aluminium trichloride; Zersetzung des Produktes mit Wasser;

Reference yield:

aluminium trichloride (7446-70-0) + 2-Methoxynaphthalene (93-04-9) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-(2-methoxy-1-naphthyl)-2-oxoacetate (22531-51-7)

Guidance literature:

upstream raw materials:

2-Methoxynaphthalene

Ethyl oxalyl chloride

aluminium trichloride

4-chloro-1-methyl-naphthalene

Downstream raw materials:

ethyl (2-methoxy-1-naphthyl)(2,6-xylylhydrazono)acetate

2-methoxy-1-naphthaldehyde

2-methoxy-1-naphthoic acid

(2-Methoxy-[1]naphthylmethylen)-anilin

Refernces

• 1、 Beccalli, Egle,Benincori, Tiziana,Sannicolo, Franco. "Rearrangements of non-indolizable arylhydrazones of methoxy substituted aromatic carbonyl compounds in polyphosphoric acid". . p. 238 - 264. Retrieved 2007/10/02.