4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile
CAS No.:161196-62-9
Molecular Formula:C₄₀H₄₄ClN₃O₂Si
Molecular Weight:662.347
Hs Code.:

Synonyms:4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

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Chemical Property of 4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

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Technology Process of 4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

There total 9 articles about 4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 161196-61-8
4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

: 161196-62-9
4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: With formic acid; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 161196-62-9
4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / hexamethylenetetramine / acetic acid; H₂O / 1 h / 120 °C

2: 1.) NaH; 2.) NaH, I₂ / 1.) DME, 0 degC; 2.) 25-40 degC

3: Li₂CO₃ / dimethylformamide / 16 h / 80 °C

4: NaBH₄ / methanol / 1 h / -10 °C

5: NaHTe / ethanol / 3 h / Ambient temperature

6: 1.) Im; 2.) NaBH₄, CaCl₂ / 1.) DMF, room t., 3 h; 2.) i-PrOH, room t., 22 h

7: 94 percent / Im / dimethylformamide / Ambient temperature

8: 69 percent / HCOOH-H₂O / tetrahydrofuran / 18 h / Ambient temperature

With sodium tetrahydroborate; formic acid; sodium hydrogen telluride; hexamethylenetetramine; impramine; iodine; lithium carbonate; sodium hydride; calcium chloride; In tetrahydrofuran; methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 161196-62-9
4'-[1-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Im / dimethylformamide / Ambient temperature

2: 69 percent / HCOOH-H₂O / tetrahydrofuran / 18 h / Ambient temperature

With formic acid; impramine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9