1318129-92-8

Usage

Molecular Class

Pyrrolidine derivatives

Explanation

It belongs to a class of chemical compounds that have a pyrrolidine ring in their structure.

Explanation

A benzyl group (C6H5CH2-) is attached to the nitrogen atom in the pyrrolidine ring, which influences its chemical properties and reactivity.

Explanation

A carboxylic acid group (-COOH) is present at the 2-position of the pyrrolidine ring, contributing to its acidity and ability to form salts or esters.

Explanation

A hydroxyl group (-OH) is attached at the 4-position of the pyrrolidine ring, making it a hydroxypyrrolidine derivative and affecting its polarity and hydrogen bonding capabilities.
5. Methyl Ester Form

Explanation

The carboxylic acid group is present as a methyl ester (-COOCH3), which influences its reactivity, volatility, and solubility.

Explanation

It can be used as a building block for the synthesis of novel molecules with biological activities, making it a valuable compound in drug development.
7. Importance in Chemical Research and Development

Explanation

Its specific properties and potential uses make it an important compound for further research and development in various fields.

Benzyl Group Attachment

Nitrogen atom of the pyrrolidine ring

Carboxylic Acid Group

2-position

Hydroxyl Group Attachment

4-position

Potential Applications

Pharmaceutical industry

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 63397-15-9 methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 100-39-0 benzyl bromide 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 67-56-1 methanol 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 
• 1318129-56-4 (2S,4S)-methyl 1-benzyl-4-(phenylcarbonyloxy)pyrrolidine-2-carboxylate 
• 101979-12-8 2(S)-4-cis-N-benzyl-4-hydroxyproline 

Downstream Products

• 1318129-14-4 (3R,5R)-3-azido-1-benzyl-5-fluoropiperidine 
• 1318129-17-7 (2S,4R)-2-(azidomethyl)-1-benzyl-4-fluoropyrrolidine 
• 1318129-36-0 (3R,5R)-1-benzyl-5-fluoropiperidin-3-amine 
• 1318129-07-5 ((2S,4R)-1-benzyl-4-fluoropyrrolidin-2-yl)methanol 
• 1318128-57-2 (2S,4S)-2-(azidomethyl)-1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine 
• 1318128-54-9 (3R,5S)-3-azido-1-benzyl-5-(tert-butyldimethylsilyloxy)piperidine 
• 635299-82-0 (3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine 
• 1318129-60-0 (2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate 
• 635299-92-2 (3S,5S)-1-benzyl-5-hydroxymethylpyrrolidin-3-ol 
• 913831-96-6 cis-1-benzylpiperidine-3,5-diol 

Relevant academic research and scientific papers

TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS

The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathi

A sub-milligram-synthesis protocol for in vitro screening of HDAC11 inhibitors

This work demonstrated the high efficiency of a sub-milligram-synthesis based medicinal chemistry method. Totally 72 compounds, consisting a tri-substituted pyrrolidine core, were prepared. Around 0.1 mg of each compound was solid-phase synthesized. Based on the additive property of UV absorptions of unconjugated chromophores of a molecule, these compounds were quantified by UV measurement. A hit, whose IC50 value was 1.2 μM in HDAC11 inhibition assays, highlights the applicability of the approach reported here in future optimization works.

Synthesis of (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives by an epimerization-lactamization cascade reaction

An epimerization-lactamization cascade of functionalized (2S,4R)-4-aminoproline methyl esters is developed and applied in synthesizing (1R,4R)-2,5-diazabicyclo[2.2.1]heptane (DBH) derivatives. (2S,4R)-4-Aminoproline methyl esters are likely to undergo 2-epimerization under basic conditions, followed by an intramolecular aminolysis of the (2R)-epimer to form the bridged lactam intermediates. Key factors identified for this cascade reaction include the electron-withdrawal N-protective group in the substrates and a strong base as the promoter.

1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

Provided are 1-(dihydronaphthalenyl)pyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy for the treatment of obesity and diabetes.

Access to optically active 3-azido- and 3-aminopiperidine derivatives by enantioselective ring expansion of prolinols

The activation of N-alkyl prolinols by XtalFluor E allowed the formation of an aziridinium intermediate that can react with tetrabutylammonium azide (nBu4NN3) to produce 3-azidopiperidines and/or 2-(azidomethyl)pyrrolidines, in a rat