2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Base Information

• Chemical Name: 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine
• CAS No.: 1287686-14-9
• Molecular Formula: C₁₅H₁₃BrF₃N₃O
• Molecular Weight: 388.187
• Mol file: 1287686-14-9.mol

Synonyms:2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Chemical Property of 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

There total 2 articles about 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-5-bromopyrazine (374063-92-0) + methanesulfonic acid 1-(4-trifluoromethylbenzyl)azetidin-3-yl ester (1146157-73-4) → 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine (1287686-14-9)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 12h;

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine (1287686-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,1-dichloroethane / 1 h / 80 °C

1.2: 16 h / 20 °C

1.3: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 12 h / 80 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; acetonitrile;

Reference yield:

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine (1287686-14-9) → benzyl 4-(5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazin-2-yl)piperazine-1-carboxylate (1287686-16-1)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 12h; Inert atmosphere;

upstream raw materials:

4-Trifluoromethylbenzaldehyde

2-hydroxy-5-bromopyrazine

methanesulfonic acid 1-(4-trifluoromethylbenzyl)azetidin-3-yl ester

Downstream raw materials:

benzyl 4-(5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazin-2-yl)piperazine-1-carboxylate

2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine