1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

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Chemical Name:1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol
CAS No.:141263-58-3
Molecular Formula:C₂₁H₃₄Cl₂O₃Si
Molecular Weight:433.491
Hs Code.:

Synonyms:1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

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Chemical Property of 1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

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Technology Process of 1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

There total 3 articles about 1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 141263-57-2
1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-D-erythro-1,2,4-hexanetriol

: 67-64-1
acetone

: 141263-58-3
1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

Guidance literature:: With 2-Methoxypropene; toluene-4-sulfonic acid; at 20 ℃; for 0.666667h;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 101910-02-5,101910-03-6,141263-55-0
(3R,5R)-5-[2-(2,4-Dichloro-phenyl)-ethyl]-tetrahydro-furan-2,3-diol

: 141263-58-3
1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 95.6 percent / NaBH₄ / ethanol / 1 h / 0 °C

2: 78.8 percent / pyridine / 3 h / Ambient temperature

3: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

With pyridine; sodium tetrahydroborate; 2-Methoxypropene; toluene-4-sulfonic acid; In ethanol;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 141263-56-1
6-(2,4-Dichlorophenyl)-D-erythro-1,2,4-hexanetriol

: 141263-58-3
1-O-tert-Butyldimethylsilyl-6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: 78.8 percent / pyridine / 3 h / Ambient temperature

2: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

With pyridine; 2-Methoxypropene; toluene-4-sulfonic acid;
DOI:10.1016/S0008-6215(00)90500-7