2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester
CAS No.:627511-97-1
Molecular Formula:C₃₉H₇₀O₈Si₂
Molecular Weight:723.151
Hs Code.:

2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

Synonyms:2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 562-98-1
triethylsilyl trifluoroacetate

: 627511-96-0
2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-4,10-dihydroxy-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

: 627511-97-1
2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tetlet.2003.08.082

Reference yield:

: 3282-30-2
pivaloyl chloride

: 627511-97-1
2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: Hg(ClO₄)2; CaCO₃ / tetrahydrofuran; H₂O / 0 °C

3: 89 percent / aq. HF / acetonitrile / 40 °C

4: H₂ / Pd/C / ethyl acetate / 20 °C

5: PPTS / CH₂Cl₂ / 20 °C

6: 54 percent / PPTS / CH₂Cl₂ / 20 °C

7: 93 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; mercury(II) perchlorate; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; triethylamine; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tetlet.2003.08.082

Reference yield:

: 209340-30-7
(S)-2-((S)-2-Benzyloxy-4-trityloxy-butyl)-oxirane

: 627511-97-1
2,2-Dimethyl-propionic acid 2-{(2S,4S,6R,8S,10S)-8-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-4,10-bis-triethylsilanyloxy-1,7-dioxa-spiro[5.5]undec-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / n-BuLi; HMPA / tetrahydrofuran / -20 °C

2: DIBALH / CH₂Cl₂; hexane / 20 °C

3: Et₃N / CH₂Cl₂ / 20 °C

4: Hg(ClO₄)2; CaCO₃ / tetrahydrofuran; H₂O / 0 °C

5: 89 percent / aq. HF / acetonitrile / 40 °C

6: H₂ / Pd/C / ethyl acetate / 20 °C

7: PPTS / CH₂Cl₂ / 20 °C

8: 54 percent / PPTS / CH₂Cl₂ / 20 °C

9: 93 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; mercury(II) perchlorate; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tetlet.2003.08.082