N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide

Base Information

• Chemical Name: N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide
• CAS No.: 174635-64-4
• Molecular Formula: C₂₅H₂₂N₂O₂
• Molecular Weight: 382.462
• Mol file: 174635-64-4.mol

Synonyms:N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide

Chemical Property of N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide

There total 5 articles about N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-1-phenylpropylamine (52500-61-5) + 2-phenylquinoline-4-carbonyl chloride (59661-86-8) → N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide (174635-64-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jm980633c

Reference yield:

1-phenyl-propane-1,2-dione 1-oxime (25355-34-4) → N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide (174635-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / H₂ / PtO₂ / aq. ethanol / 18 h / 1810.02 Torr

2: K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm980633c

Reference yield:

1-phenyl-acetone (103-79-7,136675-26-8) → N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide (174635-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 9.7 g / aq. NaNO₂, AcOH, / dioxane / Ambient temperature

2: 40 percent / H₂ / PtO₂ / aq. ethanol / 18 h / 1810.02 Torr

3: K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With hydrogen; potassium carbonate; acetic acid; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm980633c

upstream raw materials:

2-hydroxy-1-phenylpropylamine

2-phenylquinoline-4-carbonyl chloride

cinchophen

1-phenyl-propane-1,2-dione 1-oxime