4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

Base Information

Chemical Name:4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide
CAS No.:913078-94-1
Molecular Formula:C₂₃H₂₅F₃N₂O₆S₂
Molecular Weight:546.589
Hs Code.:

Synonyms:4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

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Chemical Property of 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

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Technology Process of 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

There total 10 articles about 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

: 40724-47-8
4-bromomethyl-benzenesulfonamide

: 913078-94-1
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 1.5h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-94-1
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 69 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-94-1
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 69 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067