4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

Base Information

Chemical Name:4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine
CAS No.:1333501-33-9
Molecular Formula:C₃₃H₆₁NO₆Si
Molecular Weight:595.936
Hs Code.:

Synonyms:4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

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Chemical Property of 4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

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Technology Process of 4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

There total 4 articles about 4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1333501-32-8
4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethylpiperidine-1-oxyl radical

: 57181-82-5
4-bromo-isobutylbenzene

: 1333501-33-9
4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

Guidance literature:: With copper(II) trifluoroacetate; copper; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 75 ℃; for 72h; Inert atmosphere;
DOI:10.1002/chem.201100543

Reference yield:

: 77544-60-6
p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

: 1333501-33-9
4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 60 °C / Inert atmosphere

3.1: copper(II) trifluoroacetate; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 72 h / 75 °C / Inert atmosphere

With 1H-imidazole; copper(II) trifluoroacetate; copper; sodium hydride; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201100543

Reference yield:

: 112-60-7
Tetraethylene glycol

: 1333501-33-9
4-[2-(2-{2-[2-(tert-butyldimethylsilyloxy)ethoxy]ethoxy}ethoxy)ethoxy]-2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 60 °C / Inert atmosphere

4.1: copper(II) trifluoroacetate; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 72 h / 75 °C / Inert atmosphere

With 1H-imidazole; copper(II) trifluoroacetate; copper; sodium hydride; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201100543