(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Base Information

Chemical Name:(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine
CAS No.:322392-06-3
Molecular Formula:C₂₂H₃₁NO₃
Molecular Weight:357.493
Hs Code.:

Synonyms:(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Suppliers and Price of (1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

There total 5 articles about (1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 322392-02-9
(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-1-phenylethylamine

: 322392-06-3
(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Guidance literature:: With sodium cyanoborohydride; In water; acetonitrile; at 20 ℃; for 6h;
DOI:10.1016/S0957-4166(00)00343-8

Reference yield:

: 5703-21-9
3,4-dimethoxyphenylacetaldehyde

: 322392-06-3
(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Na₂SO₄ / diethyl ether / 0.08 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

3.1: NaBH₄ / methanol / 0.5 h / 20 °C

4.1: 91 percent / NaBH₃CN / acetonitrile; H₂O / 6 h / 20 °C

With sodium tetrahydroborate; sodium cyanoborohydride; sodium sulfate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; acetonitrile; 1.1: Substitution / 2.1: deprotonation / 2.2: Alkylation / 3.1: Reduction / 4.1: Methylation;
DOI:10.1016/S0957-4166(00)00343-8

Reference yield:

: 64715-85-1,91298-74-7,127180-88-5
(R)-2-methoxy-1-phenylethylamine

: 322392-06-3
(1R,2'S)-(-)-N-[2'-(3,4-dimethoxyphenyl)butyl]-2-methoxy-N-methyl-1-phenylethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Na₂SO₄ / diethyl ether / 0.08 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

3.1: NaBH₄ / methanol / 0.5 h / 20 °C

4.1: 91 percent / NaBH₃CN / acetonitrile; H₂O / 6 h / 20 °C

With sodium tetrahydroborate; sodium cyanoborohydride; sodium sulfate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; acetonitrile; 1.1: Substitution / 2.1: deprotonation / 2.2: Alkylation / 3.1: Reduction / 4.1: Methylation;
DOI:10.1016/S0957-4166(00)00343-8