135267-12-8

Basic information

• Product Name: 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran
• Synonyms: 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran;2-[(1R)-1-[(2R)-2-(2,4-Difluorophenyl)oxiranyl]ethoxy]tetrahydro-2H-pyran
• CAS NO: 135267-12-8
• Molecular Weight: 284.303
• EINECS: -0
• Mol File: 135267-12-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran(135267-12-8)
• EPA Substance Registry System: 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran(135267-12-8)

Safety Data

• Hazardous Substances Data: 135267-12-8(Hazardous Substances Data)

Usage

Chemical class

Tetrahydro-2H-pyrans

Chirality

Chiral compound with "R" configuration

Structure

Tetrahydro-2H-pyran ring with a side chain

Side chain components

Oxiran-2-yl group and difluorophenyl moiety

Ethoxy group presence

Ethoxy group attached to the side chain

Potential applications

Pharmaceutical or agrochemical industries

Need for further research

To understand its potential uses and biological activity

Upstream product

• 1774-47-6 trimethylsulfoxonium iodide 
• 127001-03-0 (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 144025-04-7 (2,4-difluorophenyl)magnesium bromide 
• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 
• 110-87-2 3,4-dihydro-2H-pyran 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 126918-16-9 (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one 

Downstream Products

• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 134779-41-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 135133-23-2 (3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol 
• 210562-49-5 (2R,3R)-2-(2,4-difluorophenyl)-3-(piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-65-5 C₂₅H₂₈F₂N₆O 
• 1266605-67-7 C₂₅H₂₇F₃N₆O 
• 1266605-69-9 C₂₅H₂₇ClF₂N₆O 
• 1266605-73-5 (2R,3R)-2-(2,4-difluorophenyl)-3-[4-(5-fluoro-1H-indol-3-ylmethyl)-piperazin-1-yl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-75-7 C₂₅H₂₇ClF₂N₆O 
• 1266605-76-8 C₂₅H₂₇BrF₂N₆O 
• 1266605-77-9 C₂₆H₃₀F₂N₆O 
• 1266605-79-1 C₂₅H₂₇F₂N₇O₃ 
• 1266605-80-4 C₂₆H₃₀F₂N₆O₂ 
• 1266605-81-5 C₂₅H₂₇F₂N₉O 

Relevant articles and documents

NOVEL METHOD FOR PREPARATION OF EPOXYTRIAZOLE DERIVATIVES

The present invention relates to novel processes for preparing epoxytriazole derivatives. The method of claim 1, further comprising the step of adding a base to the intermediate compound. The present invention relates to an epoxytriazole derivative and a manufacturing method thereof. Chemical Formula 1. Here, Ar denotes C. 6 -C10 Aryl group or C aryl group2 -C9 The aryl group 1 -4 is substituted or unsubstituted, and when 2 or more halogen is substituted, the heteroaryl group may be the same as or different from each other, and the heteroaryl group is represented by 1 -4 fluorine, chlorine, or C. 1 -C3 Substituted or unsubstituted alkyl groups, and fluorine, chlorine, or C. 1 -C3 When more than 2 substituents are substituted, each of these substituents may be the same or different and may be different from each other. The A is C. 1 -C3 Represents an alkyl group, and the R represents an alkyl group. 1 And R2 Is a methyl group or an ethyl group.

Triazole alcohol derivative, and preparation method and application thereof

The invention relates to a triazole alcohol derivative, and a preparation method and an application thereof. The chemical structure of the triazole alcohol derivative is represented by formula I, A inthe formula I represents a benzene ring or a substituted benzene ring, and the substituent group of the substituted benzene ring can be located at each position of the benzene ring, is monosubstituted or polysubstituted, and is selected from: a) halogen which is F, Cl, Br or I; b) an electron-withdrawing group, wherein the electron withdrawing group is a cyano group, a nitro group or a trifluoromethyl group; c) a C1-4 low alkyl group or a halogen-substituted low alkyl group; and d) a C1-4 low alkoxy group or a halogen-substituted low alkoxy group. The compound has the advantages of high antifungal activity, low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal medicines.

Synthesis and activity of novel indole linked triazole derivatives as antifungal agents

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