Technology Process of 4-(4-methylphenyl)-2,6-diacetylpyridine
There total 3 articles about 4-(4-methylphenyl)-2,6-diacetylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine; methylmagnesium chloride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 0 ℃;
DOI:10.1016/j.tetlet.2012.11.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dichloromethane / 2 h / 0 - 20 °C
2.1: potassium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux
3.1: tetrahydrofuran / 3 h / 0 - 20 °C
3.2: 0 °C
With
palladium diacetate; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.tetlet.2012.11.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux
2.1: tetrahydrofuran / 3 h / 0 - 20 °C
2.2: 0 °C
With
palladium diacetate; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1016/j.tetlet.2012.11.004
