4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine

Base Information

• Chemical Name: 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine
• CAS No.: 1422463-82-8
• Molecular Formula: C₂₂H₂₅N₃O₂
• Molecular Weight: 363.459
• Mol file: 1422463-82-8.mol

Synonyms:4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine

Chemical Property of 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine

There total 2 articles about 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-bromo-2,6-bis(1-pyrrolidinylcarbonyl)pyridine (1422463-81-7) + 4-methylphenylboronic acid (5720-05-8) → 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine (1422463-82-8)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.11.004

Reference yield:

4-bromopyridine-2,6-dicarbonyl dibromide (120491-93-2) → 4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine (1422463-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 0 - 20 °C

2: potassium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; dichloromethane; water;

DOI:10.1016/j.tetlet.2012.11.004

Reference yield: 72.0%

4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine (1422463-82-8) + methylmagnesium chloride (676-58-4) → 4-(4-methylphenyl)-2,6-diacetylpyridine (1422463-85-1)

Guidance literature:

4-(4-methylphenyl)-2,6-bis(1-pyrrolidinylcarbonyl)pyridine; methylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1016/j.tetlet.2012.11.004

upstream raw materials:

4-bromopyridine-2,6-dicarbonyl dibromide

4-bromo-2,6-bis(1-pyrrolidinylcarbonyl)pyridine

4-methylphenylboronic acid

Downstream raw materials:

4-(4-methylphenyl)-2,6-pyridinedicarbaldehyde

4-(4-methylphenyl)-2,6-diacetylpyridine