1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

Base Information

Chemical Name:1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole
CAS No.:617700-03-5
Molecular Formula:C₁₂H₄Cl₂F₆I₂N₂O
Molecular Weight:630.882
Hs Code.:

Synonyms:1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

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Chemical Property of 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

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Technology Process of 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

There total 3 articles about 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 617700-02-4
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

: 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]iodopyrazole

: 617700-03-5
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

Guidance literature:: 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo034520z

Reference yield:

: 617699-98-6
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole

: 617700-03-5
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1021/jo034520z

Reference yield:

: 617699-97-5
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole

: 617700-03-5
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 79 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; isopropylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1021/jo034520z