1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

Base Information

Chemical Name:1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole
CAS No.:617700-05-7
Molecular Formula:C₁₂H₂Cl₂F₆I₂N₂O
Molecular Weight:628.866
Hs Code.:

Synonyms:1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

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Technology Process of 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

There total 4 articles about 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 617700-03-5
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

: 617700-05-7
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1021/jo034520z

Reference yield:

: 617699-98-6
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole

: 617700-05-7
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

3.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo034520z

Reference yield:

: 617699-97-5
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole

: 617700-05-7
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodo-4-(trifluoroacetyl)pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 79 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

4.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; isopropylmagnesium chloride; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo034520z