2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester
CAS No.:174874-23-8
Molecular Formula:C₂₉H₄₉BrO₉SSi
Molecular Weight:681.758
Hs Code.:

2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

Synonyms:2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

There total 6 articles about 2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 124-63-0
methanesulfonyl chloride

: 143660-65-5
2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3R)-3-[(R)-1-hydroxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

: 174874-23-8
2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

Guidance literature:: With dmap; TEA; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1016/S0040-4039(00)74257-2

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 174874-23-8
2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 97 percent / D-(-)-DIPT, Ti(OPrⁱ)4, 4 Angstroem-MS / CH₂Cl₂ / 72 h / -20 °C

3: 100 percent / TEA, DMAP / CH₂Cl₂ / 1 h / -40 °C

With titanium(IV) isopropylate; dmap; 4 Angstroem-MS; TEA; D-(-)-diisopropyl tartrate; In dichloromethane;
DOI:10.1016/S0040-4039(00)74257-2

Reference yield:

: 3282-30-2
pivaloyl chloride

: 174874-23-8
2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 97 percent / D-(-)-DIPT, Ti(OPrⁱ)4, 4 Angstroem-MS / CH₂Cl₂ / 72 h / -20 °C

3: 100 percent / TEA, DMAP / CH₂Cl₂ / 1 h / -40 °C

With titanium(IV) isopropylate; dmap; 4 Angstroem-MS; TEA; D-(-)-diisopropyl tartrate; In dichloromethane;
DOI:10.1016/S0040-4039(00)74257-2