4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

Base Information

Chemical Name:4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol
CAS No.:1262414-29-8
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

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Chemical Property of 4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

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Technology Process of 4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

There total 16 articles about 4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-29-8
4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / methanol / 24 h / Reflux

3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

4.1: ammonia / methanol / 18 h / 60 °C

5.1: trifluoroacetic anhydride; pyridine / dichloromethane / 1 h / 0 °C

6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 18 h / 60 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 49 h / 20 - 115 °C

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

With pyridine; methanol; sulfuric acid; hydroxylamine hydrochloride; ammonia; hydrogen; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-29-8
4-[3-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 6 steps

1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2: ammonia / methanol / 18 h / 60 °C

3: trifluoroacetic anhydride; pyridine / dichloromethane / 1 h / 0 °C

4: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 18 h / 60 °C

5: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 49 h / 20 - 115 °C

6: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

With pyridine; hydroxylamine hydrochloride; ammonia; hydrogen; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;