(1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide

Base Information

• Chemical Name: (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide
• CAS No.: 172016-01-2
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.364
• Mol file: 172016-01-2.mol

Synonyms:(1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide

Chemical Property of (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide

There total 8 articles about (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methylmagnesium bromide (75-16-1) + (1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide (172016-00-1) → (1S,2R)-1-phenyl-2-<(S)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide (171889-13-7) + (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide (172016-01-2)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 2h;

DOI:10.1021/jo9518056

Reference yield: 90.0%

(1S,2R)-1-phenyl-2-acetyl-N,N-diethylcyclopropanecarboxamide (171889-17-1) → (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide (172016-01-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1021/jo9518056

Reference yield: 90.0%

ethylmagnesium bromide (925-90-6) + (1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide (172016-00-1) → (1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide (172016-01-2) + (1S,2R)-2-((S)-1-Hydroxy-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide (171889-14-8)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 2h;

DOI:10.1021/jo9518056

upstream raw materials:

methylmagnesium bromide

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

(1S,2R)-1-phenyl-2-acetyl-N,N-diethylcyclopropanecarboxamide

ethylmagnesium bromide

Downstream raw materials:

(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

(1S,2R)-1-phenyl-2-<(R)-1-azidoethyl>-N,N-diethylcyclopropanecarboxamide

(1S,4R,5R)-2-oxo-4-ethyl-1-phenyl-3-oxabicyclo[3.1.0]hexane