(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

Base Information

Chemical Name:(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine
CAS No.:769961-18-4
Molecular Formula:C₁₇H₂₁F₃N₂O₅
Molecular Weight:390.359
Hs Code.:

Synonyms:(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

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Chemical Property of (R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

Chemical Property:

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Technology Process of (R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

There total 4 articles about (R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59378-81-3,69610-40-8,83435-58-9
1-(tert-butoxycarbonyl)prolin-2R-ol

: 612498-85-8
3-nitro-6-trifluoromethylphenol

: 769961-18-4
(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/jm070034i

Reference yield:

: 453560-74-2
2-methoxy-4-nitro-1-(trifluoromethyl)benzene

: 769961-18-4
(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride / 2 h / 210 °C

2: 6.36 g / triphenylphosphine; DEAD / tetrahydrofuran / 18 h / 20 °C

With pyridine hydrochloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1021/jm070034i

Reference yield:

: 5458-84-4
2-iodo-5-nitroanisole

: 769961-18-4
(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / copper; pyridine / 22 h / 140 °C

2: pyridine hydrochloride / 2 h / 210 °C

3: 6.36 g / triphenylphosphine; DEAD / tetrahydrofuran / 18 h / 20 °C

With pyridine; pyridine hydrochloride; copper; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 3: Mitsunobu reaction;
DOI:10.1021/jm070034i