453560-74-2

Basic information

• Product Name: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene
• Synonyms: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene;5-nitro-2-(trifluoromethy)anisole
• CAS NO: 453560-74-2
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.1333496
• Mol File: 453560-74-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 46-48°
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene(453560-74-2)
• EPA Substance Registry System: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene(453560-74-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 453560-74-2(Hazardous Substances Data)

Usage

General Description

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is a chemical compound with the molecular formula C8H6F3NO3. It is a nitro-substituted trifluoromethylbenzene with a methoxy group attached to one of the carbon atoms. 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the production of dyes, pigments, and other specialty chemicals. 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is known to be toxic if ingested, inhaled, or in contact with skin, and proper safety precautions should be taken when handling this chemical.

Upstream product

• 2314-97-8 iodotrifluoromethane 
• 5458-84-4 2-iodo-5-nitroanisole 
• 1514-87-0 metyhyl chlorodifluoroacetate 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1448037-95-3 C₁₃H₂₀N₄O₃ 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 77152-08-0 trifluoromethylcopper(I) 
• 2597-56-0 4-nitro-o-anisic acid 

Downstream Products

• 612498-85-8 3-nitro-6-trifluoromethylphenol 
• 106877-20-7 3-methoxy-4-(trifluoromethyl)aniline 
• 1485749-14-1 N-[4-[8-amino-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 
• 1485749-11-8 tert-butyl N-[3-[4-(methanesulfonamido)phenyl]-5-methoxy-6-(trifluoromethyl)-8-quinolyl]carbamate 
• 1257832-33-9 N-[4-[8-bromo-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 
• 694514-19-7 2-bromo-5-methoxy-4-(trifluoromethyl)aniline 
• 1257832-39-5 N-[4-[8-(2,4-dioxopyrimidin-1-yl)-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 
• 52427-05-1 2-bromo-5-nitrophenol 
• 769960-90-9 (R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine 
• 769961-13-9 (R)-3-(1-methyl-pyrrolidin-2-ylmethoxy)-4-trifluoromethyl-phenylamine 
• 769961-28-6 [2-(5-isothiocyanato-2-trifluoromethyl-phenoxy)-ethyl]-dimethyl-amine 
• 474941-22-5 3-(2-dimethylamino-ethoxy)-4-trifluoromethylaniline 
• 952490-88-9 (R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine 
• 952490-85-6 (R)-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine 

Relevant articles and documents

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF3 in aqueous media

A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF3 (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules. This journal is the Partner Organisations 2014.

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase

In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper, we