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2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is a chemical compound with the molecular formula C8H6F3NO3. It is a nitro-substituted trifluoromethylbenzene with a methoxy group attached to one of the carbon atoms.

453560-74-2

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453560-74-2 Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is used as a building block for the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is used as a building block in the synthesis of agrochemicals. Its properties make it suitable for the development of new pesticides and other agricultural chemicals.
Used in Dye and Pigment Production:
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is used as an intermediate in the production of dyes and pigments. Its chemical structure contributes to the color and stability of these products.
Used in Specialty Chemicals:
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is used as an intermediate in the production of specialty chemicals. Its unique properties make it valuable in the development of various chemical products.
Safety Precautions:
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene is known to be toxic if ingested, inhaled, or in contact with skin. Proper safety precautions, such as wearing protective clothing and using appropriate handling equipment, should be taken when working with this chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 453560-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,3,5,6 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 453560-74:
(8*4)+(7*5)+(6*3)+(5*5)+(4*6)+(3*0)+(2*7)+(1*4)=152
152 % 10 = 2
So 453560-74-2 is a valid CAS Registry Number.

453560-74-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene

1.2 Other means of identification

Product number -
Other names 5-nitro-2-trifluoromethylanisole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:453560-74-2 SDS

453560-74-2Relevant articles and documents

Deoxofluorination of (Hetero)aromatic Acids

Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.

, p. 3110 - 3124 (2020/03/23)

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

-

Page/Page column 226, (2017/03/14)

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase

Talamas, Francisco X.,Abbot, Sarah C.,Anand, Shalini,Brameld, Ken A.,Carter, David S.,Chen, Jun,Davis, Dana,De Vicente, Javier,Fung, Amy D.,Gong, Leyi,Harris, Seth F.,Inbar, Petra,Labadie, Sharada S.,Lee, Eun K.,Lemoine, Remy,Le Pogam, Sophie,Leveque, Vincent,Li, Jim,McIntosh, Joel,Nájera, Isabel,Park, Jaehyeon,Railkar, Aruna,Rajyaguru, Sonal,Sangi, Michael,Schoenfeld, Ryan C.,Staben, Leanna R.,Tan, Yunchou,Taygerly, Joshua P.,Villase?or, Armando G.,Weller, Paul E.

, p. 1914 - 1931 (2014/04/03)

In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper, we

Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF3 in aqueous media

Lishchynskyi, Anton,Berthon, Guillaume,Grushin, Vladimir V.

supporting information, p. 10237 - 10240 (2014/08/18)

A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF3 (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules. This journal is the Partner Organisations 2014.

Conversion of aromatic amino into trifluoromethyl groups through a Sandmeyer-type transformation

Wang, Xi,Xu, Yan,Zhou, Yujing,Zhang, Yan,Wang, Jianbo

supporting information, p. 2143 - 2148 (2014/08/18)

A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions. Georg Thieme Verlag Stuttgart. New York.

Trifluoromethylation of 1-aryl-3,3-diisopropyltriazenes

Hafner, Andreas,Braese, Stefan

supporting information, p. 996 - 1000 (2013/05/08)

A new method for the trifluoromethylation of functionalized aromatic diisopropyltriazenes is described. In a facile two-step, one-pot synthesis, various functionalized trifluoromethyl-substituted arenes are accessible in mostly good yields by using methyl iodide as iodination agent and the trifluoromethylation system (trifluoromethyl)trimethylsilane/potassium fluoride/copper iodide. This concept could be expanded to perfluoroethylation as well as ethoxycarbonyldifluoromethylation reactions. Copyright

Silver-mediated trifluoromethylation of aryldiazonium salts: Conversion of amino group into trifluoromethyl group

Wang, Xi,Xu, Yan,Mo, Fanyang,Ji, Guojing,Qiu, Di,Feng, Jiajie,Ye, Yuxuan,Zhang, Songnan,Zhang, Yan,Wang, Jianbo

supporting information, p. 10330 - 10333 (2013/08/23)

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

HETEROCYCLIC ANTIVIRAL COMPOUNDS

-

Page/Page column 42, (2010/12/29)

Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

-

Page/Page column 69; 70, (2010/07/08)

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.

DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS

-

Page/Page column 64-65, (2010/07/04)

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

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