(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

Base Information

Chemical Name:(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine
CAS No.:769960-90-9
Molecular Formula:C₁₄H₁₅F₃N₂OS
Molecular Weight:316.347
Hs Code.:

Synonyms:(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

Chemical Property:

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Technology Process of (R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

There total 8 articles about (R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 769961-13-9
(R)-3-(1-methyl-pyrrolidin-2-ylmethoxy)-4-trifluoromethyl-phenylamine

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 769960-90-9
(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm070034i

Reference yield:

: 952490-85-6
(R)-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

: 769960-90-9
(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / sodium cyanoborohydride / H₂O; acetonitrile / 20 °C

2: 100 percent / H₂ / Pd/C / methanol; dioxane

3: 36 percent / CH₂Cl₂ / 1 h / 0 - 20 °C

With hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm070034i

Reference yield:

: 952490-88-9
(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

: 769960-90-9
(R)-2-((5-isothiocyanato-2-(trifluoromethyl)phenoxy)methyl)-1-methylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol; dioxane

2: 36 percent / CH₂Cl₂ / 1 h / 0 - 20 °C

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm070034i