Chemical Property of N6-Methyladenosine
Chemical Property:
- Vapor Pressure:9.86E-18mmHg at 25°C
- Melting Point:172 °C
- Refractive Index:1.814
- Boiling Point:649.1 °C at 760 mmHg
- PKA:13.12±0.70(Predicted)
- Flash Point:346.3 °C
- PSA：125.55000
- Density:1.85 g/cm3
- LogP:-1.44750
- Storage Temp.:−20°C
- XLogP3:-0.4
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:3
- Exact Mass:281.11240398
- Heavy Atom Count:20
- Complexity:349
- Purity/Quality:
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98%, *data from raw suppliers
N6-Methyladenosine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O
- Isomeric SMILES:CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
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Description
N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.
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Uses
N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
