methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate

Base Information

• Chemical Name: methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate
• CAS No.: 256488-02-5
• Molecular Formula: C₁₆H₂₁NO₅S
• Molecular Weight: 339.412

Synonyms:methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate

Chemical Property of methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate

Chemical Property:

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Technology Process of methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate

There total 2 articles about methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1N-tert-butoxycarbonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate (256488-01-4) → methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate (256488-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 1 h / 20 °C

2: Et₃N / CH₂Cl₂ / 18 h

With triethylamine; trifluoroacetic acid; In dichloromethane; 1: Hydrolysis / 2: sulfonylation;

DOI:10.1021/jm9904699

Reference yield:

4-n-propoxy-1-benzenesulfonyl chloride (58076-32-7) + (R)-4-Methylene-pyrrolidine-2-carboxylic acid methyl ester → methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate (256488-02-5)

Guidance literature:

With triethylamine; In dichloromethane; for 18h;

DOI:10.1021/jm9904699

Reference yield:

methyl 1N-(4-n-propyloxyphenyl)-sulfonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate (256488-02-5) → (R)-4-Methylene-1-(4-propoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide

Guidance literature:

With hydroxylamine; In methanol; at 20 ℃;

DOI:10.1021/jm9904699

upstream raw materials:

4-n-propoxy-1-benzenesulfonyl chloride

methyl 1N-tert-butoxycarbonyl-4-exomethylene-pyrrolidine-(2R)-carboxylate

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