(2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine

Base Information

• Chemical Name: (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzo
• Molecular Formula: C₂₅H₂₆N₂
• Molecular Weight: 354.495

Synonyms:(2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine

Chemical Property of (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzo

Chemical Property:

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There total 2 articles about (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aniline hydrochloride (142-04-1,36663-09-9) + (7α,11bα)-1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-one (86457-11-6) → (2α,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine (75715-72-9) + (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine (75715-73-0)

Guidance literature:

With sodium cyanoborohydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Yield given. Yields of byproduct given; molecular sieves (Linde 4A);

DOI:10.1021/jm00133a017

Reference yield:

aniline hydrochloride (142-04-1,36663-09-9) + (7α,11bα)-1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-one (86457-11-6) → (2α,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine (75715-72-9) + (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine (75715-73-0) + Phenyl-((7R,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-amine

Guidance literature:

With sodium cyanoborohydride; toluene-4-sulfonic acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) toluene, reflux, 5.25 h, 2.) THF, 0 deg C, 30 min, molecular sieves (Linde 4A);

DOI:10.1021/jm00133a017

Reference yield: 15.0%

propionyl chloride (79-03-8) + Phenyl-((7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-amine (75715-67-2,75715-68-3,75715-72-9,75715-73-0,83509-76-6,91549-02-9) → N-(2β,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-yl)-N-phenylpropanamide (75688-92-5,75715-64-9,75715-65-0,75715-66-1) + N-(2α,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-yl)-N-phenylpropanamide (75688-92-5,75715-64-9,75715-65-0,75715-66-1)

Guidance literature:

In dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/jm00133a017

upstream raw materials:

aniline hydrochloride

(7α,11bα)-1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-one

Downstream raw materials:

C₂₆H₂₅ClN₂O*ClH

1,1-Dimethyl-3-phenyl-3-((2R,7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-urea

N-(2β,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-yl)-N-phenylpropanamide

N-(2α,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzoquinolizin-2-yl)-N-phenylpropanamide

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