N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide

Base Information

• Chemical Name: N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide
• CAS No.: 118974-48-4
• Molecular Formula: C₁₉H₃₁N₃O₄
• Molecular Weight: 365.473
• Mol file: 118974-48-4.mol

Synonyms:N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide

Chemical Property of N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide

There total 2 articles about N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-[2-(2-chloroethoxy)ethyl]acetamide. N-[2-(2-hydroxyethoxy)ethyl]acetamide (118974-47-3) + benzylamine (100-46-9) → N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide (118974-48-4)

Guidance literature:

With sodium carbonate; In toluene; for 48h; Heating;

DOI:10.1021/jo00278a016

Reference yield:

N-[2-(2-hydroxyethoxy)ethyl]acetamide (118974-46-2) → N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide (118974-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: 71 percent / anhydrous Na₂CO₃ / toluene / 48 h / Heating

With thionyl chloride; sodium carbonate; In toluene;

DOI:10.1016/0040-4039(88)85282-1

Reference yield: 73.0%

N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide (118974-48-4) → 9-benzyl-3,9,15-triaza-6,12-dioxaheptadecane (118974-42-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1021/jo00278a016

upstream raw materials:

N-[2-(2-chloroethoxy)ethyl]acetamide. N-[2-(2-hydroxyethoxy)ethyl]acetamide

benzylamine

N-[2-(2-hydroxyethoxy)ethyl]acetamide

Downstream raw materials:

9-benzyl-3,9,15-triaza-6,12-dioxaheptadecane

4-benzyl-10,16-diethyl-4,10,16-triaza-1,7,13-trioxacyclooctadecane

10-Benzyl-4,16-diethyl-1,7,13-trioxa-4,10,16-triaza-cyclooctadecane-3,17-dione

4-<(allyloxy)methyl>-4-benzyl-10,19-diethyl-4,10,19-triaza-1,7,13,16-tetraoxycycloheneicosane