tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

Base Information

Chemical Name:tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate
CAS No.:1392437-21-6
Molecular Formula:C₃₂H₃₅F₃N₄O₇
Molecular Weight:644.648
Hs Code.:

tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

Synonyms:tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

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Chemical Property of tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

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Technology Process of tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

There total 7 articles about tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 808793-56-8
3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

: 1392437-19-2
tert-butyl(cis)-9-hydroxy-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

: 1392437-21-6
tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 50 - 55 ℃; for 1.66667h; Large scale;

Reference yield:

: 1263475-15-5
tert-butyl (cis)-9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecane-4-carboxylate

: 1392437-21-6
tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 2-methyltetrahydrofuran / 0.75 h / 3 - 25 °C / Large scale

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.67 h / 50 - 55 °C / Large scale

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1392437-21-6
tert-butyl(trans)-9-(3-benzyl-7-methoxy-4-oxo-3,4-dihydro-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)-1,4-diaza-spiro[5.5]undecane-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane; water / 5 °C / Large scale

1.2: 19.5 h / 5 - 15 °C / Large scale

2.1: hydrogenchloride / 1,4-dioxane; acetic acid / 2.58 h / 80 - 100 °C / Large scale

3.1: sodium methylate / methanol; acetonitrile / 3 h / 20 °C / Large scale

3.2: 16 h / Large scale

4.1: potassium carbonate; dmap / acetonitrile / 2.17 h / Large scale

5.1: sodium tetrahydroborate / water / 0.53 h / 3 °C / Large scale

6.1: triethylamine / 2-methyltetrahydrofuran / 0.75 h / 3 - 25 °C / Large scale

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.67 h / 50 - 55 °C / Large scale

With hydrogenchloride; dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; N-benzyl-N,N,N-triethylammonium chloride; sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; acetonitrile;