phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

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Chemical Name:phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate
CAS No.:1161076-46-5
Molecular Formula:C₂₄H₁₉ClFN₅O₂
Molecular Weight:463.899
Hs Code.:

Synonyms:phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

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Chemical Property of phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

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Technology Process of phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

There total 5 articles about phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161076-92-1
4,5,6,7-tetrahydro-3-hydroxy-7-[(phenylmethoxy)carbonyl][1,2,3]oxadiazolo[3,4-b]pyridazin-8-ium inner salt

: 1161076-87-4
2-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-[2-(methylthio)-4-pyrimidinyl]pyrazolo[1,5-a]pyridine

: 1161076-46-5
phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Guidance literature:: In 1,3,5-trimethyl-benzene; at 140 ℃; for 4h;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1161076-46-5
phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 18 h / 20 °C / Inert atmosphere

2: 1,3,5-trimethyl-benzene / 18 h / 165 °C

3: 1,3,5-trimethyl-benzene / 4 h / 140 °C

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,3,5-trimethyl-benzene;

Reference yield:

: 65632-62-4
(3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester

: 1161076-46-5
phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / water / 3.5 h / 4 °C

2: trifluoroacetic anhydride / diethyl ether / 3.5 h / 0 - 2 °C

3: 1,3,5-trimethyl-benzene / 4 h / 140 °C

With hydrogenchloride; trifluoroacetic anhydride; sodium nitrite; In diethyl ether; water; 1,3,5-trimethyl-benzene;