phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Base Information

• Chemical Name: phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate
• CAS No.: 1161076-94-3
• Molecular Formula: C₂₇H₂₇FN₆O₃
• Molecular Weight: 502.548
• Mol file: 1161076-94-3.mol

Synonyms:phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Chemical Property of phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

There total 7 articles about phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-1-propanol (6168-72-5) + phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate (1161076-46-5) → phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate (1161076-94-3)

Guidance literature:

In chloroform; at 120 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) → phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate (1161076-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 18 h / 20 °C / Inert atmosphere

2: 1,3,5-trimethyl-benzene / 18 h / 165 °C

3: 1,3,5-trimethyl-benzene / 4 h / 140 °C

4: chloroform / 1 h / 120 °C / Sealed tube; Microwave irradiation

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In chloroform; 1,3,5-trimethyl-benzene;

Reference yield:

1-(phenylmethyl) hydrogen tetrahydro-2-nitrosopyridazine-1,(3S)(2H)-dicarboxylate (1161076-91-0) → phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate (1161076-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic anhydride / diethyl ether / 3.5 h / 0 - 2 °C

2: 1,3,5-trimethyl-benzene / 4 h / 140 °C

3: chloroform / 1 h / 120 °C / Sealed tube; Microwave irradiation

With trifluoroacetic anhydride; In diethyl ether; chloroform; 1,3,5-trimethyl-benzene;

upstream raw materials:

2-Amino-1-propanol

phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate

1-ethynyl-4-fluorobenzene

(3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester

Downstream raw materials:

2-[[4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazin-3-yl]-2-pyrimidinyl]amino]-1-propanol