3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

Base Information

Chemical Name:3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine
CAS No.:204329-83-9
Molecular Formula:C₁₇H₂₅F₃N₂OSi
Molecular Weight:358.479
Hs Code.:

Synonyms:3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

Chemical Property:

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Technology Process of 3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

There total 9 articles about 3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)diaziridine

: 204329-83-9
3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: With tert-butylhypochlorite; triethylamine; Yield given. Multistep reaction; 1.) Et2O, -50 deg C; 2.) Et2O, -50 deg C -> room temp.;
DOI:10.1246/cl.1998.203

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 204329-83-9
3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide

2: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

3: 91 percent / NH₂OH*HCl, Et₃N / ethanol / Heating

4: 98 percent / pyridine / 0 deg C -> room temp.

5: 98 percent / liq. NH₃ / diethyl ether / -78 -> -33 deg C -> room temp.

6: 1.) t-BuOCl; 2.) Et₃N / 1.) Et₂O, -50 deg C; 2.) Et₂O, -50 deg C -> room temp.

With pyridine; 1H-imidazole; n-butyllithium; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.203

Reference yield:

: 75567-84-9
methyl 3-(4-bromopehynl)propanoate

: 204329-83-9
3-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / LiAlH₄ / diethyl ether / Heating

2: imidazole / dimethylformamide

3: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

4: 91 percent / NH₂OH*HCl, Et₃N / ethanol / Heating

5: 98 percent / pyridine / 0 deg C -> room temp.

6: 98 percent / liq. NH₃ / diethyl ether / -78 -> -33 deg C -> room temp.

7: 1.) t-BuOCl; 2.) Et₃N / 1.) Et₂O, -50 deg C; 2.) Et₂O, -50 deg C -> room temp.

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.203