Technology Process of (2R,3R,4R)-1-Benzyl-3-benzyloxy-4-fluoro-2-vinyl-pyrrolidine
There total 3 articles about (2R,3R,4R)-1-Benzyl-3-benzyloxy-4-fluoro-2-vinyl-pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2R,5S)-3-Benzyl-2-vinyl-6-oxa-3-aza-bicyclo[3.1.0]hexane;
With
pyridine hydrogenfluoride;
at 60 ℃;
for 24h;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
benzyl bromide;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1002/ejoc.200300163
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 71 percent / Ph3P; CCl4; Et3N / dimethylformamide / 20 °C
2.1: HF*pyridine / 24 h / 60 °C
2.2: NaH / tetrahydrofuran / 0 °C
2.3: 584 mg / tetrabutylammonium iodide / tetrahydrofuran / 20 °C
With
tetrachloromethane; pyridine hydrogenfluoride; triethylamine; triphenylphosphine;
In
N,N-dimethyl-formamide;
1.1: Appel cyclization;
DOI:10.1002/ejoc.200300163
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 87 percent / TBAF on silica gel / tetrahydrofuran
2.1: 71 percent / Ph3P; CCl4; Et3N / dimethylformamide / 20 °C
3.1: HF*pyridine / 24 h / 60 °C
3.2: NaH / tetrahydrofuran / 0 °C
3.3: 584 mg / tetrabutylammonium iodide / tetrahydrofuran / 20 °C
With
tetrachloromethane; tetrabutyl ammonium fluoride; pyridine hydrogenfluoride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2.1: Appel cyclization;
DOI:10.1002/ejoc.200300163
