357278-33-2

Upstream product

• 100-46-9 benzylamine 
• 131484-41-8 erythro-(2R,3S)-4-(tert-butyldimethylsiloxy)-2,3-epoxy-1-butanol 
• 87770-83-0 (Z)-4-((tert-butyldiphenylsilyl)oxy)but-2-en-1-ol 
• 131380-35-3 (2R,3R)-4-(tert-Butyldiphenylsilyloxy)-2,3-epoxybutan-1-al 
• 1826-67-1 vinyl magnesium bromide 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 357278-39-8 (4R,5S)-3-benzyl-5-((1S)-2-tert-butyldiphenylsilyloxy-1-hydroxyethyl)-4-vinyl-1,3-oxazolan-2-one 
• 357278-43-4 (2S,3S,4R)-4-Benzylamino-2-benzyloxy-hex-5-ene-1,3-diol 
• 357278-45-6 (2R,3S,4S)-1-Benzyl-4-benzyloxy-2-vinyl-pyrrolidin-3-ol 
• 129077-29-8 (S)-1-((2R,3S,4S)-1-Benzyl-3,4-bis-benzyloxy-pyrrolidin-2-yl)-ethane-1,2-diol 
• 608514-64-3 (R)-1-((2R,3R,4R)-1-Benzyl-3,4-bis-benzyloxy-pyrrolidin-2-yl)-ethane-1,2-diol 
• 608514-58-5 (2R,3R,4R)-1-Benzyl-3,4-bis-benzyloxy-2-vinyl-pyrrolidine 
• 608514-66-5 (R)-1-((2R,3R,4R)-1-Benzyl-3-benzyloxy-4-fluoro-pyrrolidin-2-yl)-ethane-1,2-diol 
• 608514-62-1 (2R,3R,4R)-1-Benzyl-3-benzyloxy-4-fluoro-2-vinyl-pyrrolidine 
• 357278-44-5 (2R,3R,4R)-1-Benzyl-2-vinyl-pyrrolidine-3,4-diol 
• 606933-30-6 (R)-1-((2R,3R,4R)-4-Fluoro-3-hydroxy-pyrrolidin-2-yl)-ethane-1,2-diol 
• 357278-44-5 (2R,3S,4S)-1-Benzyl-2-vinyl-pyrrolidine-3,4-diol 
• 357278-46-7 (1R,2R,5S)-3-Benzyl-2-vinyl-6-oxa-3-aza-bicyclo[3.1.0]hexane 
• 113200-91-2 (2R,3R,4R)-N-benzyl-3,4-bis(benzyloxy)-2-hydroxymethylpyrrolidine 
• 129077-19-6 (2R,3S,4S)-1-Benzyl-3,4-bis-benzyloxy-2-vinyl-pyrrolidine 

Relevant academic research and scientific papers

New approach to carbamoyl-polyoxamic acid derivatives through an oxazolidinone synthon

A key oxazolidinone synthon was obtained through condensation of vinyl magnesium with an epoxyimine, followed by a carbonation/cyclisation reaction in the presence of ammonium carbonate. Oxidative ozonolysis after protection and carbamolylation (optional)

Asymmetric syntheses of (-)-lentiginosine and an original pyrrolizidinic analogue thereof from a versatile epoxyamine intermediate

Ready access to natural (-)-lentiginosine and its pyrrolizidinic analogue from a chiral vinylic epoxyamine in a straightforward five-step sequence is presented. Careful use of the RCM reaction on aminotriols 5 and 6 constitutes the key feature of the synt

Stereoselective access to the versatile 4-aminohex-5-ene-1,2,3-triol pattern

We developed a stereocontrolled route allowing potential access to the eight isomers of 4-benzyl-aminohex-5-ene-1,2,3-triol in two or four steps and ca. 50% yield from readily available chiral nonracemic cis- or trans-α,β-epoxyimine precursors. A new (NH

A new access to polyhydroxylated pyrrolidines from epoxyaldehydes

Our approach relies on the stereocontrolled vinylation of a chiral α,β-epoxyimine derived from the corresponding aldehyde. Regioselective opening of the oxirane with carbonate anion allowed the formation of an oxazolidinone intermediate from which the glu