3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

Base Information

Chemical Name:3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione
CAS No.:1365546-06-0
Molecular Formula:C₃₀H₂₆ClNO₅
Molecular Weight:515.993
Hs Code.:

Synonyms:3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

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Chemical Property of 3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

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Technology Process of 3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

There total 4 articles about 3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1365546-05-9
2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione

: 65136-48-3
4-(3-chloropropoxy)benzoic acid chloride

: 1365546-06-0
3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

Guidance literature:: With tin(IV) chloride; In dichloromethane; at 0 - 25 ℃; for 1h;
DOI:10.1021/op300017v

Reference yield: 76.0%

: 1365546-05-9
2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione

: 65136-52-9
4-(3-chloropropoxy)benzoic acid

: 1365546-06-0
3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

Guidance literature:: With phosphorus pentoxide; at 35 ℃; for 1.25h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op300017v

Reference yield:

: 85-44-9
phthalic anhydride

: 1365546-06-0
3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; toluene / 0.5 h / Large scale reaction

1.2: 1.5 h / Reflux

2.1: phosphorus pentoxide / 1.25 h / 35 °C / Inert atmosphere; Large scale reaction

With phosphorus pentoxide; sodium hydrogencarbonate; In water; toluene; 2.1: Friedel Crafts acylation;
DOI:10.1021/op300017v