1365546-05-9

Basic information

• Product Name: 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione
• Synonyms: 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione
• CAS NO: 1365546-05-9
• Molecular Weight: 319.36
• Mol File: 1365546-05-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione(1365546-05-9)
• EPA Substance Registry System: 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione(1365546-05-9)

Safety Data

• Hazardous Substances Data: 1365546-05-9(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 526196-90-7 2-n-butyl-5-aminobenzofuran hydrochloride 

Downstream Products

• 1365546-07-1 C₃₈H₄₄N₂O₅ 
• 141644-91-9 (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 
• 500791-70-8 5-amino-2-n-butyl-3-[4-(3-di-n-butylamino propoxy)benzoyl]benzofuran bisoxalate 
• 141626-36-0 dronedarone 
• 141625-93-6 dronedarone hydrochloride 
• 1365546-06-0 3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione 

Relevant articles and documents

Preparation method of dronedarone hydrochloride key intermediate

The invention relates to a preparation method of a dronedarone hydrochloride key intermediate. The preparation method comprises following steps: 1) 2-butyl-benzofuran-5-ylamine hydrochloride and phthalic anhydride are subjected to reflux reaction under alkaline conditions so as to protect amino groups; and 2) 4-[3-(dibutyl amino) propoxy] benzoic acid is added into Eaton's reagent for stirring reaction, an intermediate 1 is added, temperature is controlled for reaction, a free amine is obtained via treatment, and the free amine and oxalic acid are subjected to salt forming reaction so as to obtain compound IV 5-amino-2-n-butyl-3-[4-(3-n-dibutyl aminopropoxy) benzoyl]benzofuran oxalate. The dronedarone hydrochloride key intermediate is prepared by taking 2-butyl-benzofuran-5-ylamine hydrochloride as the starting raw material; production of the dronedarone free amino is high in selectivity, and high in yield; fewer steps are needed; so that the preparation method is suitable for industrialized production.