3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Base Information

Chemical Name:3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine
CAS No.:1347759-42-5
Molecular Formula:C₃₁H₂₈IN₃O₂
Molecular Weight:601.487
Hs Code.:

Synonyms:3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

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Chemical Property of 3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

There total 7 articles about 3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1347759-40-3
4-chloro-3-iodo-6-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1347759-42-5
3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Tetrahydro-pyran-4-ol; With sodium hydride; In 1,4-dioxane; mineral oil; for 0.166667h;

4-chloro-3-iodo-6-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridine; In 1,4-dioxane; mineral oil; at 180 ℃; for 1h; Microwave irradiation;

Reference yield:

: 138642-40-7
methyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 1347759-42-5
3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

5.1: triethylamine / dichloromethane / 3.08 h / 20 °C

6.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

6.2: 1 h / 180 °C / Microwave irradiation

With oxalyl dichloride; iodine; sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; potassium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; toluene; mineral oil;

Reference yield:

: 374800-25-6
2,4-Dichloro-3-hydroxymethyl-6-methylpyridine

: 1347759-42-5
3-iodo-6-methyl-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

3.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

4.1: triethylamine / dichloromethane / 3.08 h / 20 °C

5.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

5.2: 1 h / 180 °C / Microwave irradiation

With oxalyl dichloride; iodine; sodium hydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; potassium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; mineral oil;