Technology Process of 6-methyl-3-(1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine
There total 8 articles about 6-methyl-3-(1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate; sodium carbonate;
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II);
In
water; acetonitrile;
at 150 ℃;
for 0.5h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C
3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C
4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C
5.1: triethylamine / dichloromethane / 3.08 h / 20 °C
6.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h
6.2: 1 h / 180 °C / Microwave irradiation
7.1: sodium carbonate; potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation
With
oxalyl dichloride; iodine; potassium acetate; sodium hydride; diisobutylaluminium hydride; sodium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; potassium hydroxide;
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II);
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C
2.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C
3.1: triethylamine / dichloromethane / 3.08 h / 20 °C
4.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h
4.2: 1 h / 180 °C / Microwave irradiation
5.1: sodium carbonate; potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation
With
iodine; potassium acetate; sodium hydride; sodium carbonate; hydrazine hydrate; triethylamine; potassium hydroxide;
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II);
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; mineral oil;
