6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

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Chemical Name:6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine
CAS No.:1347759-45-8
Molecular Formula:C₃₉H₃₉N₅O₃
Molecular Weight:625.77
Hs Code.:

Synonyms:6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

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Chemical Property of 6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

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Technology Process of 6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

There total 9 articles about 6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134419-59-3
4-oxanyl methanesulfonate

: 1347759-44-7
6-methyl-3-(1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1347759-45-8
6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

Reference yield:

: 138642-40-7
methyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 1347759-45-8
6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

5.1: triethylamine / dichloromethane / 3.08 h / 20 °C

6.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

6.2: 1 h / 180 °C / Microwave irradiation

7.1: sodium carbonate; potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

8.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

With oxalyl dichloride; iodine; potassium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium carbonate; caesium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; potassium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 86129-63-7
ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 1347759-45-8
6-methyl-3-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / -78 - -30 °C

1.2: -30 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

5.1: triethylamine / dichloromethane / 3.08 h / 20 °C

6.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

6.2: 1 h / 180 °C / Microwave irradiation

7.1: sodium carbonate; potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

8.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

With lithium aluminium tetrahydride; oxalyl dichloride; iodine; potassium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; caesium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; potassium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;